Courses
MBGE 433
The key concepts and techniques related to the molecular and cellular basis of microbial pathogenesis including the exploitation of mammalian host cells by medically relevant prokaryotic and eukaryotic pathogens, molecular mechanisms of infectious diseases, immune response to infections, the role of pathogenic and host factors in disease and emerging techniques to study the basis of microbial pathogenesis and disease.
MBGE 423
The key concepts and techniques related to the prokaryotic and eukaryotic cytoskeleton including the molecular mechanism of the core building blocks, nucleators, molecular motors and regulators of actin and microtubule cytoskeleton and intermediate filaments, roles of the cytoskeleton in the physiology of individual cells, tissues and organisms and their implications in human disease, emerging techniques to study the cytoskeletal components such as advanced microscopy.
MBGE 415
Broad cross section of methodological approaches including cloning, genomic strategies, single molecule and single cell-based studies, in situ localization, high troughput approaches such as RNAi, gene expression analysis, genetic approaches with model systems as well as techniques for protein analysis.
MBGE 408
Proteomics and function, fundamentals of mass spectrometry (MS), tandem MS, chemical and posttranslational modifications, protein identification, data mining, protein complexes, protein folding, MS genotyping, high throughput; recently developed proteomics methods and their applications; focus on the recent scientific literature in this field including quantitative comparison of healthy and disease proteomes, the comprehensive analysis of protein-protein interactions in different cell types, and new approaches to analyze cellular signaling pathways and the subcellular-organelle and cell surface proteomes.
MBGE 404
Molecular details of the innate and adaptive immune systems. Subject areas will include immune recognition, immunosuppression, communication between different immune system cell types, and autoimmunity.
MBGE 430
Fundamental aspects of molecular and cellular biology of cancers with respect to developing cancer therapies; basic principles of cancer treatment, molecularly targeted therapies, cytotoxic therapies, drug discovery approaches, drug delivery systems, cell-based and gene therapies; discussion of research and review articles.
MBGE 418
The journey of a fertilized egg to turn into a fully developed adult, the molecular mechanisms that regulate the animal development in two vertebrate (mouse, fish) and two invertebrate (fly, worm) models; body plan formation, organogenesis, morphogenesis, regeneration and ageing.
MBGE 410
Cells have elaborate mechanisms for controlling cell proliferation and differentiation. In this course, we will explore in molecular detail the intricate signaling pathways that are important for cell behavior, with a major focus on those pathways that are conserved widely among many species.
MBGE 405
The key areas of RNA biology, structure and function; splicing, polyadenylation, transport, translation and decay of mRNAs; the regulatory mechanisms governed by noncoding RNAs such as siRNAs, miRNAs and long noncoding RNAs.
MBGE 395
Students will carry out independent research under the supervision of a faculty in the field of molecular biology and genetics.
MBGE 432
Stem cell biology at the intersection of developmental/cell biology and medicine; overview of stem cell biology in the context of embryonic development, tissue maintenance and cancer. Embryonic and induced pluripotent stem cells, reprogramming and differentiation, stem cells in adult tissues and cancer, therapeutic applications of stem cells. Advanced molecular and cellular techniques to study, generate and manipulate stem cells.
MBGE 420
Function of different neuronal cell types and the larger organization of the mammalian nervous system: The topics include the molecular details of synaptic connectivity and its relationship to learning and memory and the causes of neurodegenerative disease.
MBGE 412
Fundamental aspects of the molecular and cellular biology of tumor formation and cancer cells. Topics include cell cycle, oncogenes, tumor suppressor genes, the tumor's interaction with other cells and tissues, approaches to treating cancer, and novel experimental approaches for the discovery of mutations that contribute to tumorigenesis.
MBGE 407
This course covers the cell and molecular biology of pathogenic organisms, such as malaria, trypanosomes, toxoplasma, and parasitic yeast. Topics will include organism life cycles, host invasion strategies, methods of immune system evasion, and the evolution of parasites.
MBGE 403
How do cells generate, store, and use the energy that they require? This course will cover in great depth the processes of oxidative phosphorylation, glycolysis, and photosynthesis. In addition, energy acquisition by chemotrophic organisms will be discussed.