Proteomics and function, fundamentals of mass spectrometry (MS), tandem MS, chemical and posttranslational modifications, protein identification, data mining, protein complexes, protein folding, MS genotyping, high throughput; recently developed proteomics methods and their applications; focus on the recent scientific literature in this field including quantitative comparison of healthy and disease proteomes, the comprehensive analysis of protein-protein interactions in different cell types, and new approaches to analyze cellular signaling pathways and the subcellular-organelle and cell surface proteomes.

Broad cross section of methodological approaches including cloning, genomic strategies, single molecule and single cell-based studies, in situ localization, high troughput approaches such as RNAi, gene expression analysis, genetic approaches with model systems as well as techniques for protein analysis.

The key concepts and techniques related to the prokaryotic and eukaryotic cytoskeleton including the molecular mechanism of the core building blocks, nucleators, molecular motors and regulators of actin and microtubule cytoskeleton and intermediate filaments, roles of the cytoskeleton in the physiology of individual cells, tissues and organisms and their implications in human disease, emerging techniques to study the cytoskeletal components such as advanced microscopy.

The key concepts and techniques related to the molecular and cellular basis of microbial pathogenesis including the exploitation of mammalian host cells by medically relevant prokaryotic and eukaryotic pathogens, molecular mechanisms of infectious diseases, immune response to infections, the role of pathogenic and host factors in disease and emerging techniques to study the basis of microbial pathogenesis and disease.

Introduction to computational biology and insight into the newest approaches for generating and analyzing large datasets from biological systems. Specifically, an understanding of microarray analysis, "deep sequencing," mass spectroscopic analysis and proteomics, sequence alignment and identification of motifs within DNA and protein molecules, clustering coordinately regulated genes and proteins, and structural modeling.

Cells have elaborate mechanisms for controlling cell proliferation and differentiation. In this course, we will explore in molecular detail the intricate signaling pathways that are important for cell behavior, with a major focus on those pathways that are conserved widely among many species.

The journey of a fertilized egg to turn into a fully developed adult, the molecular mechanisms that regulate the animal development in two vertebrate (mouse, fish) and two invertebrate (fly, worm) models; body plan formation, organogenesis, morphogenesis, regeneration and ageing.

Fundamental aspects of molecular and cellular biology of cancers with respect to developing cancer therapies; basic principles of cancer treatment, molecularly targeted therapies, cytotoxic therapies, drug discovery approaches, drug delivery systems, cell-based and gene therapies; discussion of research and review articles.

Advanced theoretical and applied methods in modern genomic research; classical and novel approaches used to solve problems in functional genomics and system biology; modern sequencing techniques and their utilization in biomedical research.