Mechanisms Controlling Accurate Chromosome Segregation in Budding Yeast


Dr. Ayşe Koca Çaydaşı, Assistant Professor, Gebze Technical University

Faithful chromosome segregation in budding yeast requires correct positioning of the mitotic spindle along the mother-to-daughter cell polarity axis. The Mitotic Exit Network (MEN) drives cells out of mitosis, whereas the Spindle Position Checkpoint (SPOC) blocks MEN activity when the anaphase spindle is mis-positioned. How SPOC works on a molecular level remains unclear. Here, I will discuss the role of yeast centrosomes in SPOC regulation and present novel mechanisms that orchestrate chromosome segregation in time and space.